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Pharmacology and Toxicology of Metiamide, a Histamine H<sub>2</sub> - Receptor Antagonist


R. W. Brimblecombe
W.A.M. Duncan
M.E. Parsons

Abstract

A brief review of the pharmacology and toxicology of metiamide, a histamine H2-receptor antagonist, is given, and evidence is presented to support the view that it inhibits gastric acid secretion by virtue of its H2-receptor antagonist activity. Studies are also reported which show that metiamide given either intravenously or intraduodenally inhibits histamine- or pentagastrin-stimulated acid secretion in human subjects.


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eISSN: 2078-5135
print ISSN: 0256-9574