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Volume of the Rat
Abstract
Chromium (51Cr)-EOTA was used to estimate extracellular fluid volume and glomerular filtration rate of the rat. In rats with protein energy malnutrition and oedema (kwashiorkor), there was a significant increase in extracellular fluid volume (30 et 24 mllloo g), but no change in glomerular filtration rate. An infusion of angiotensin (0,3 to 1,4 ng/g/min) produced a decrease in both glomerular filtration rate and in the rate .of urine formation, suggesting that an increase in the activity of the reninangiotensin system may contribute to the development of oedema associated with protein energy malnutrition, by opposing the excretion of urine by the kidneys.
