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Clinical trial of a new diuretic-metindamide


P. Burger
I.F. Anderson

Abstract

A controlled clinical trial of metindamide (N-(3-sulphamoyl 1 - 4 chlorobenzamido) - 2 - methyl indoline), is reported. It was compared with furosemide in 15 normal subjects and 15 patients with cardiac oedema. Metindamide was found to be at least as effective as furosemide, and produced a greater water loss, but an equivalent electrolyte loss. It had a slow onset, and a fairly prolonged effect, making it a less aggressive drug than furosemide, and one which is suitable for maintenance therapy. In a smaller trial its effect as a hypotensive agent was demonstrated. The drug was well tolerated and side-effects were minimal.

S. Afr. Med. J., 48, 546 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574