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Oxyphenbutazone and flufenamic acid in the treatment of osteo-arthritis of the knee


G.H. Erdmann

Abstract

Patients suffering from osteo-arthritis of the knee were admitted to a double-blind trial comparing the efficacy and tolerability of oxyphenbutazone (Tanderil) and flufenamic acid. Objective and subjective parameters were measured to assess the anti-inflammatory activity of the trial medication. Tolerability and side-effects were evaluated by subjective statement. Fifty patients entered the trial. On the 7th day of treatment oxyphenbutazone was found to be significantly superior to flufenamic acid in improving stiffness and the patient's feeling of well-being. Oxyphenbutazone significantly reduced pain on the 3rd day of treatment, compared with flufenamic acid. No serious side-effects were encountered.

S. Afr. Med. J., 48, 947 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574