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South African Medical Journal

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Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus

M Mendelson, Z Barday, R Eastman, D Le Feuvre, S Candy, H Wu, C Swanepoel

Abstract


Sirolimus, a potent inhibitor of B- and T-cell activation, is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus.



http://dx.doi.org/10.7196/SAMJ.5500
AJOL African Journals Online