Toxicity study in mice of resins of three Commiphora species

  • Yalemtsehay Mekonnen Department of Biology, Faculty of Science Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
  • Aman Dekebo Department of Chemistry, Faculty of Science, Addis Ababa University, PO Box 1176, Addis Ababa Ethiopia
  • Ermias Dagne Department of Chemistry, Faculty of Science, Addis Ababa University, PO Box 1176, Addis Ababa Ethiopia
Keywords: Commiphora erlangeriana, C. guidotti, C. myrrha, myrrh, opopanax

Abstract

Acute toxicity studies of crude extracts of resins of Commiphora myrrha, C. guidottii and C. erlangeriana, and pure compounds isolated from C. erlangeriana were conducted on Swiss albino mice. The extract from C. erlangeriana had a mean LD50 of 410 mg/kg body weight. However the extracts from C. myrrha and C. guidotti were not toxic at the doses tested. The pure compound isolated from C. erlangeriana, erlangerin D (1) demonstrated a mean LD50 of 140 mg/kg body weight. On the other hand erlangerin A (2) was not toxic to the mice at even four times the LD50 value of erlangerin D (1).
Key words/phrases: Commiphora erlangeriana, C. guidotti, C. myrrha, myrrh, opopanax
SINET: Ethiopian Journal of Science Vol.26(2) 2003: 151-153
Published
2005-01-31
Section
Articles

Journal Identifiers


eISSN: 2520-7997
print ISSN: 0379-2897