Lipid profile of alloxan-induced diabetic wistar rats treated with methanolic extract of <i>Adansonia digitata</i> fruit pulp

Abstract

This study was carried out to assess the antidiabetic properties of
Adansoniadigitata fruit pulp by evaluating the effect of its methanolic
extract (MAD) on cholesterol, High Density Lipoprotein (HDL), Low Density
Lipoprotein (LDL) and triglycerides. Forty eight male wistar/albino rats
weighing 160 to 240 g were randomly distributed into six treatment groups
[Group1, Normal control, each given only 0.2 ml distilled water daily for 4
weeks; Group 2, diabetes control rats, induced with 150 mg/kg b.w., i.p.
administration of alloxan and thereafter given 0.2 ml distilled water
throughout the study period; Groups 3, 4 and 5, diabetic (i.p., 150 mg/kg
b.w. alloxan) rats were given single oral dose of MAD (100, 200 and 300
mg/kg b.w. respectively) for 4 weeks; Group 6, diabetic rats (i.p., 150
mg/kg b.w. alloxan) were treated with 84 mg/kg b.w. of Chloropropamide,
once daily for 4 weeks]. The serum concentration of cholesterol, HDL, LDL
and triglycerides of all the animals in each group were determined after the
14th and 28th treatment. There was significant (P<0.001) reduction of
serum cholesterol, LDL and Triglycerides when compared with the diabetic
control rats. These reductions were dose dependent and compared well
with values obtained in the standard drug control group. Significant
(P<0.001) increase in HDL were seen in the MAD experimental groups but
differed significantly (P<0.001) with reduction seen in chloropropamide
group.

Keywords: Antidiabetic property, Adansoniadigitata fruit pulp, Lipid profile,
Wistar Rats