Two hundred (200) strains of S. aureus and P. aeruginosa were isolated from clinical samples collected from patients in Murtala Muhammad Specialist Hospital and Infectious Diseases Hospital, Kano. The confirmed isolates were tested for resistance to quinolones by the agar disk diffusion susceptibility test and the agar dilution minimum inhibitory concentration test. A resistance prevalence rate of 27% and 38% were seen in S. aureus and P. aeruginosa respectively. Eighteen S. aureus isolates were resistant to only one quinolone, while 9 had multiple resistances. 25 P. aeruginosa isolates were resistant to one quinolone, while 13 had multiple resistances. Nine resistance patterns were observed in all the isolates with S. aureus isolates having 8 while P. aeruginosa had 7. There was no significant difference (p>0.05) in the resistances observed in S. aureus and P. aeruginosa isolated from the male or female atients except in the case of 2 S. aureus isolates that were resistant to sparfloxacin. Quinolones could still be relied upon as effective antibiotics in treating S. aureus and P. aeruginosa infections. The need to emphasize enforcement of antibiotic use policies in developing countries is further justified by these findings.
Keywords: Resistance, Quionolones, S. aureus, P. aeruginosa,