APOPO’s tuberculosis research agenda: achievements, challenges and prospects

  • Negussie Beyene APOPO-Sokoine University of Agriculture
  • Amanda Mahoney Department of Psychology, Western Michigan University, Kalamazoo, Michigan,
  • Christophe Cox APOPO-Sokoine University of Agriculture
  • Bart Weetjens APOPO-Sokoine University of Agriculture
  • George Makingi Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro
  • Georgies Mgode Pest Management Centre, Morogoro
  • Amy Durgin APOPO, Sokoine University of Agriculture, Morogoro
  • Dian Kuipers APOPO, Sokoine University of Agriculture, Morogoro
  • Maureen Jubitana APOPO, Sokoine University of Agriculture, Morogoro
  • Said Egwaga National Tuberculosis and Leprosy Programme, Ministry of Health and Social Welfare, Dar es Salam
  • Deus Kamara National Tuberculosis and Leprosy Programme, Ministry of Health and Social Welfare, Dar es Salam
  • Fred Lwilla National Tuberculosis and Leprosy Programme, Ministry of Health and Social Welfare, Dar es Salam
  • Sayoki G. Mfinanga National Institute for Medical Research, Muhimbil Research Centre, Dar es Salaam
  • Amos Kahwa National Institute for Medical Research, Muhimbil Research Centre, Dar es Salaam
  • Robert Machang'u Pest Management Centre, Sokoine University of Agriculture, Morogoro
  • Rudovick Kazwala Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro
  • Klaus Reither Swiss Tropical and Public Health Institute, Basel
  • Stefan H.E. Kaufmann Department of Immunology, Max Planck Institute for Infection Biology, Berlin
  • Alan Poling Department of Psychology, Western Michigan University, Kalamazoo, Michigan
Keywords: Tuberculosis detection, sniffer rats, Cricetomys gambianus, olfaction, Mycobacterium tuberculosis

Abstract

This article describes Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO) recent use of specially trained African giant pouched rats as detectors of pulmonary tuberculosis in people living in Tanzania. It summarizes the achievements and challenges encountered over the years and outlines future prospects. Since 2008, second-line screening by the rats has identified more than 2000 tuberculosis-positive patients who were missed by microscopy at Direct Observation of Treatment – Short Course centres in Tanzania.  Moreover, data that are reviewed herein have been collected with respect to the rats’ sensitivity and specificity in detecting tuberculosis. Findings strongly suggest that scent-detecting rats offer a quick and practical tool for detecting pulmonary tuberculosis and within the year APOPO’s tuberculosis-detection project will be extended to Mozambique.  As part of its local capacity building effort, APOPO hires and trains Tanzanians to play many important roles in its TB detection project and provides research and training opportunities for Tanzanian students.

Published
2012-04-21
How to Cite
BeyeneN., MahoneyA., CoxC., WeetjensB., MakingiG., MgodeG., DurginA., KuipersD., JubitanaM., EgwagaS., KamaraD., LwillaF., MfinangaS. G., KahwaA., Machang’uR., KazwalaR., ReitherK., KaufmannS. H., & PolingA. (2012). APOPO’s tuberculosis research agenda: achievements, challenges and prospects. Tanzania Journal of Health Research, 14(2). https://doi.org/10.4314/thrb.v14i2.5
Section
Articles

Journal Identifiers


eISSN: 1821-9241
print ISSN: 1821-6404