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Changes in plasma lipid peroxide and ascorbic acid levels in diabetes mellitus and clinical significance in an urban, Nigerian population
Abstract
Design and method: This study was conducted on the relationship between plasma lipid peroxides, ascorbic acid levels and diabetes mellitus. Forty two diabetic patients (24 males and 18 females) age grouped between 40 - 60 years were studied in the diabetic clinic of Federal Medical Centre Owerri. Controls were patients who had normal fasting blood sugar levels.
Results: This study revealed a significant increase in plasma lipid peroxidase levels ( using) malondialdehyde-MDA- as marker for lipid perioxidation) in diabetic patients ( 6.27±0.52nmol MDA/ml) when compared to the plasma lipid peroxide level in control group (4.98±0.52) nmol MDA/ml) at P<0.05. The plasma lipid peroxidase levels increased with increase in plasma glucose concentrations. Also plasma Vitamin C in patients with diabetes mellitus (58.2± 4.9 mmol/l significantly decreased (P<0.05) when compared to plasma Vitamin C levels in control group (78.3±7.4mmol/l). The plasma lipid peroxide levels were slightly higher but not statistically significant in diabetic males (6.57±0.54nmolMDA/ml) as compared to diabetic females (7.0±0.47nmol MDA/ml). Also the plasma Vitamin C levels in diabetic males (60.0±5.2mmol/l) was not statistically significant when compared to the concentration (56.5± nmol/l in diabetic females (P>0.05).
Conclusions: this study therefore revealed that an increase in lipid perioxidation products and the decrease in antioxidant vitamin C are associated with diabetes mellitus and that vitamin C supplementation or that gotten from natural foods should serve as an added advantage to protect the patients with diabetes mellitus.
Tropical Journal of Medical Research 2004;8(2): 32-35
Results: This study revealed a significant increase in plasma lipid peroxidase levels ( using) malondialdehyde-MDA- as marker for lipid perioxidation) in diabetic patients ( 6.27±0.52nmol MDA/ml) when compared to the plasma lipid peroxide level in control group (4.98±0.52) nmol MDA/ml) at P<0.05. The plasma lipid peroxidase levels increased with increase in plasma glucose concentrations. Also plasma Vitamin C in patients with diabetes mellitus (58.2± 4.9 mmol/l significantly decreased (P<0.05) when compared to plasma Vitamin C levels in control group (78.3±7.4mmol/l). The plasma lipid peroxide levels were slightly higher but not statistically significant in diabetic males (6.57±0.54nmolMDA/ml) as compared to diabetic females (7.0±0.47nmol MDA/ml). Also the plasma Vitamin C levels in diabetic males (60.0±5.2mmol/l) was not statistically significant when compared to the concentration (56.5± nmol/l in diabetic females (P>0.05).
Conclusions: this study therefore revealed that an increase in lipid perioxidation products and the decrease in antioxidant vitamin C are associated with diabetes mellitus and that vitamin C supplementation or that gotten from natural foods should serve as an added advantage to protect the patients with diabetes mellitus.
Tropical Journal of Medical Research 2004;8(2): 32-35
