Tropical Journal of Medical Research

Log in or Register to get access to full text downloads.

Remember me or Register

DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

The Anti-Diarrhea Properties Of Zingibier Offcinale

EC Nwoko, PC Unekwe, KC Chilaka, ED Nwobodo, CN Okwuosa


Introduction: The crude extract of the plant Zingiber officinale has a high folkloric reputation for anti-diarrhea activity. This study investigated the scientific basis of this folkloric claim.
Materials and Methods: Diarrhea was induced in albino mice and albino wistar rats using Castor-oil. The animals (mice) were offered the acetone extracts of the plant at 20 and 40mg/kg body weight. The albino rats (wistar) received water dose extracts of the plant. The level of protection offered by the extracts was compared with a standard anti-diarrhea agent (Diphenoxylate). The effect of the extract on the intestinal motility was also investigated.
Results: The crude extract of Z. officinale produced a comparatively high protection against castor oil- induced diarrhea in rats relative to the positive control animals that were treated with diphenoxylate. The extract shows a reduction in the transit time of ingested charcoal indicating a reduction in the intestinal motility.
Conclusion: The crude extract of Z. officinale showed a promising anti-diarrhea activity. Inhibition of the intestinal motility by the extract may underlie the observed anti-diarrhea action but previous reports show that the extracts have anti-microbial action as well. High secretions largely underlie the pathophysiology of diarrhea.

Keywords: Zingiber officinal, anti-diarrhea, rodents

Tropical Journal of Medical Research Vol. 12 (1) 2008: pp.18-21
AJOL African Journals Online