Relationship between 25‑hydroxyvitamin D and ovarian reserve in premenopausal Nigerian women

  • C.C. Makwe
  • Z Aliyu
Keywords: Anti‑Mullerian hormone, Nigerian women, ovarian reserve, premenopausal women, Vitamin D


Context: Despite the increasing knowledge about the potential effect of vitamin D deficiency on ovarian reserve of premenopausal women, the burden of this disorder among ‘at risk’ women in sub‑Saharan Africa is notably scanty.

• To determine the prevalence of vitamin D deficiency among premenopausal Nigerian women
• To assess the relationship between serum 25‑hydroxyvitamin D [25(OH)D] and serum anti‑mullerian hormone (AMH).

Settings and Design: A prospective cross‑sectional study of 218 premenopausal Nigerian women, attending a tertiary hospital in Lagos.

Materials and Methods: Serum levels of 25(OH)D and AMH were assayed using ELIZA technique, for each eligible participant.

Statistical Analysis Used: To determine the association between serum vitamin D and serum AMH were Kruskal‑Wallis test and Pearson’s correlation coefficient. Data analysis was performed on 211 participants with complete data.

Results: The mean (± SD) concentrations of serum 25(OH)D and AMH were 37.8 (± 21.4) ng/ml and 1.6 (± 0.6) ng/ml, respectively. The proportion of study participants with serum vitamin D deficiency, insufficiency and sufficiency were 18.5%, 24.6%, and 56.9%, respectively. There was no statistically significant difference in the mean serum AMH among participants with deficient, insufficient, and sufficient vitamin D levels (1.41 ng/ml versus 1.56 ng/ml versus 1.59 ng/ml, P value = 0.539). Overall, there was no correlation between serum 25(OH)D, and serum AMH (r = 0.056, P > 0.05).

Conclusion: Although the proportion of women with subnormal levels of serum vitamin D was relatively high, there was no association between serum levels of vitamin D and AMH.

Keywords: Anti‑Mullerian hormone; Nigerian women; ovarian reserve; premenopausal women; Vitamin D


Journal Identifiers

eISSN: 0189-5117