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Acetyl-cholinesterase Enzyme Inhibitory Effect of <i>Calophyllum</i> species


Gwendoline Cheng Lian Ee
Soek Sin Teh
Siau Hui Mah
Nur Ain Jamaluddin
Muhamad Syarik bin Muhamad Sahimi
Zuraini Ahmad

Abstract

Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species.

Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method.

Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.

Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.

Keywords: Calophyllum species, Acetylcholinesterase, Inhibitors


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eISSN: 1596-9827
print ISSN: 1596-5996