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Published:
Jul 31, 2007Keywords:
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Main Article Content
A Comparative Evaluation of the Flow and Compaction Characteristics of a-Cellulose obtained from Waste Paper
Abstract
Purpose: Alpha-cellulose obtained as pulp from fibrous plant materials has found use in the pharmaceutical industry as a disintegrant and direct compression diluent. The aim of this study was to evaluate the suitability of α-cellulose obtained from waste paper as a direct compression excipient.
Method: The flow and compaction characteristics of α-cellulose (ACP) obtained from waste paper, in comparison with Avicel PH 101, using the Kawakita and Heckel models were evaluated.
Result: The results indicate that the flow properties of these materials could not be predicted accurately using the Kawakita model. A comparison of compression behaviour and compactibility of the two powders showed Avicel PH 101 to be a slightly better binder. Conclusion: It was concluded that ACP material could find use as a potential dry binder and direct compression diluent in tableting as the binding properties were comparable to those of Avicel PH 101.
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Keywords: Alpha-cellulose, microcrystalline cellulose, flow and compaction characteristics, direct compression diluent.
> Tropical Journal of Pharmaceutical Research Vol. 6 (1) 2007: pp. 645-651
