Tropical Journal of Pharmaceutical Research

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Memory-enhancing effect of Rhodiola rosea L extract on aged mice

Yanjing Cao, Lizhen Liang, Xu Jian, Jiali Wu, Yongxing Yan, Ping Lin, Qiang Chen, Fengming Zheng, Qin Wang, Qian Ren, Zengmei Gou, Yongjun Fan, Yifeng Du


Purpose: The memory-enhancing effects of Rhodiola rosea L. extract (RRLE) on normal aged mice were assessed.
Methods: In the open-field test, the effect of RRLE (150 and 300 mg/kg) on mouse locomotive activities was evaluated by investigating the extract’s influence on CAT and AchE activities in the brain tissue of mice.
Results: Compared with aged group, high dose of RRLE reduced the total distance (3212.4 ± 123.1 cm, p < 0.05) significantly, increased catalase (CAT) activity (101.4 ± 12.2 U/mg pro, p < 0.05), and inhibited acetyl cholinesterase (AChE) activity (0.94 ± 0.12 U/mg pro, p < 0.05) in the brain tissue of aged mice.
Conclusion: The results show that RRLE improves the memory functions of aged mice probably by increasing CAT activity while decreasing AChE activity.

Keywords: Rhodiola rosea, Memory function, Catalase, Acetyl cholinesterase, Open-field test
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