PROMOTING ACCESS TO AFRICAN RESEARCH

Tropical Journal of Pharmaceutical Research

Log in or Register to get access to full text downloads.

Remember me or Register



Multiparticulate Drug Delivery Systems for Controlled Release

NS Dey, S Majumdar, MEB Rao

Abstract




Pharmaceutical invention and research are increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimising side effects. Recent trends indicate that multiparticulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. The release of drug from microparticles depends on a variety of factors including the carrier used to form the multiparticles and the amount of drug contained in them. Consequently, multiparticulate drug delivery systems provide tremendous opportunities for designing new controlled and delayed release oral formulations, thus extending the frontier of future pharmaceutical development.


Keywords: Dose dumping, Microparticles, Multiparticulate delivery system, Delayed release

Tropical Journal of Pharmaceutical Research Vol. 7 (3) 2008: pp. 1067-1075



http://dx.doi.org/10.4314/tjpr.v7i3.14692
AJOL African Journals Online