Application of a widely-used tropical anti-worm agent, mebendazole, in modern oncology

  • Dušica J Popović
  • Mihalj Poša
  • Kosta J Popović
  • Jovanka Kolarović
  • Jovan K. Popović
  • Pavle Z. Banović
Keywords: Anthelmintic, Mebendazole, Cancer treatment, Antimicrotubullar effect, Antineoangiogenesis

Abstract

Although clinical trials have not been completed, it has already been confirmed that mebendazole, a well-known anti-parasitic drug widely used in the tropical areas, inhibits cancer cell growth. Preclinical studies show that mebendazole notably impedes the growth of malignant and metastatic tumors such as osteosarcoma and soft tissue sarcoma, melanoma, carcinoma (lung, colorectal, breast, ovarian, hepatocellular and adrenocortical), acute myeloid leukaemia, glioblastoma multiforme and  meduloblastoma. Mebendazole can induce the depolymerization of microtubules in neoplasms and newly formed vasculature, stopping tumor growth and neoangiogenesis, along with other proposed mechanisms of action.


Keywords: Anthelmintic, Mebendazole, Cancer treatment, Antimicrotubullar effect, Antineoangiogenesis

Published
2017-11-15
Section
Articles

Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996