Effect and safety of combined Gegen Qinlian decoction/metformin in the treatment of diabetes mellitus in patients, and its influence on serum C peptide and glycosylated hemoglobin

  • Jie Chen
  • Yi Xu
  • Yan Zhao
  • Geling Liu
  • Jia Cui
  • Yan Li
  • Weijuan Li
Keywords: Serum C peptide, Glycosylated hemoglobin (HbAlc), Gegen Qinlian Decoction

Abstract

Purpose: To investigate the clinical efficacy and safety of combined Gegen Qinlian decoction /metformin in the treatment of diabetes mellitus (DM), and its influence on serum C peptide and glycosylated hemoglobin (HbAlc).
Methods: One hundred and eighty-six DM patients who received treatment in Tangshan Gongren Hospital, Tangshan City, China from July 2018 to November 2019 were randomly assigned to group X (n = 93) and group Y (n = 93). Group Y was given metformin, while X received a combination of Gegen Qinlian decoction and metformin. Total effectiveness, incidence of adverse reactions, blood glucose, TCM syndrome scores, as well as serum C peptide and HbAlc were determined and compared between the two groups.
Results: Compared with group Y, group X had significantly higher treatment effectiveness (p < 0.05), lower incidence of adverse reactions (p < 0.05), significantly lower levels of blood glucose and TCM syndrome score after treatment (p < 0.001), but significantly higher serum C-peptide levels (p < 0.001) and lower levels of HbAlc.
Conclusion: the combination of Gegen Qinlian decoction and metformin produces a good anti-diabetic efficacy, with a lower incidence of adverse reactions in patients. Therefore, the combined therapy has potentials for application in clinical practice, but further clinical trials are required.

Published
2022-06-18
Section
Articles

Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996