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Published:
Jul 11, 2026DOI:
10.4314/tjpr.v25i6.4Keywords:
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Main Article Content
Effect of superdisintegrant type and concentration on dissolution behaviour of Ondansetron orodispersible tablets
Abstract
Purpose: To investigate the effect of various superdisintegrants on disintegration time and early-phase dissolution in ondansetron hydrochloride orodispersible tablets (ODTs).
Methods: A total of 12 formulations were prepared by direct compression using a 3×4 full factorial design. Crospovidone (CPV), sodium starch glycolate (SSG), and croscarmellose sodium (CCS) were each tested at 2, 4, 6, and 8 % w/w. Primary responses were disintegration time, 5-minute drug release, dissolution similarity (f2), and Korsmeyer–Peppas exponent (n).
Results: All blends had acceptable flow properties. At 8 % w/w, CPV released 77.2 % within 5 min compared to SSG (p < 0.01), f2 = 45.3 between CPV and SSG indicated dissimilar profiles, and f2 = 90.8 between SSG and CCS confirmed equivalent swelling-polymer behaviour. Korsmeyer–Peppas modelling gave n = 0.33 for CPV (Fickian diffusion) and n = 0.45, 0.44 for SSG and CCS, respectively, consistent with partial gel-layer resistance. Korsmeyer–Peppas rate constant showed kKP = 40.09 min-n for CPV compared to 7.13 min-n and 28.50 min-n for SSG and CCS, respectively. Furthermore, CPV produced faster early drug release compared to SSG and CCS at all concentrations.
Conclusion: Crospovidone shows significantly superior early-phase dissolution at all concentrations compared with SSG and CCS
