Antiprotozoal Activity of α,β-Unsaturated δ-Lactones: Promising Compounds for the Development of New Therapeutic Alternatives

  • CG Wilson
  • SV Jairo
Keywords: Lactones, Pyrones, Antiparasitic, Antiprotozoal, Leishmania, Malaria, Chagas, Plasmodium falciparum, Tripanosoma cruzi.

Abstract

The parasite resistance and side effects of drugs used to treat protozoal diseases have led to the search for new therapies, both natural and synthetic. Studies have shown that various α,β-unsaturated δ-lactones displayed high antiprotozoal activity and thus are promising compounds for new drug discovery and development. These compounds and their activity are examined in this review.

Keywords: Lactones, Pyrones, Antiparasitic, Antiprotozoal, Leishmania, Malaria, Chagas, Plasmodium falciparum, Tripanosoma cruzi.

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Articles

Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996