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Comparison of Weibull and Probit Analysis in Toxicity Testing of <i>Hunteria umbellata</i> K Schum (Apocynaceae) Extract in Mice


SA Osagie
I Igbe
JE Osemwenkhae

Abstract

Purpose; Hunteria umbellata has been found to have therapeutic potentials in the treatments of diseases such as yaws, peptic ulcers, diabetes, piles and infertility in Nigeria; hence, the statistical analysis on the determination of acute toxicity of Hunteria umbellata was carried out in mice.
Methods; Data on the acute toxicity studies of the seed extract of Hunteria umbellata administered via the intraperitoneal route was analyzed using the two-parameter Weibull model.
Results; The median lethal dose (LD50) was 1.61 g/kg of body weight. This result falls in the neighbourhood of the median lethal dose earlier obtained in previous reports.
Conclusion; The results show that Hunteria umbellata may be slightly toxic when administered intraperitoneally.

Keywords: Hunteria umbellata, Weibull model, Acute toxicity, Median lethal dose (LD50).


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eISSN: 1596-9827
print ISSN: 1596-5996