Synthesis of some cis-4,4-dimethyl-2-isopropenylcyclopentane derivatives as potential intermediates towards the protoilludane skeleton

  • SJM Mdachi Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania


The three gem-dimethyl-substituted cyclopentane derivatives 1-(2-propionyl)-4,4-dimethyl-2-isopropenylcyclopentane, 2-isopropenyl-4,4-dimethylcyclopentanecarboxyaldehyde and 1-hydroxy- methyl-2-isopropenyl-4,4-dimethylcyclopentane have been synthesized employing a thermally induced ene reaction as a key step. Each of the three compounds has been obtained predominantly as the cis isomer. The successful synthesis of these compounds affords opportunities for their further ellaboration towards sesquiterpenes of the protoilludane skeleton.

Tanz. J. Sci. Vol.29(2) 2003: 89-94

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eISSN: 2507-7961
print ISSN: 0856-1761