Synthesis of <i>Cyclo</i> (L-Trans-(4-Hydroxyprolinyl)-L-Phenylalanine)

Abstract

The diketopiperazine Cyclo (L-trans-(4-Hydroxyprolinyl)-L-phenylalanine)1 has been synthesized by coupling a  suitably protected form of L-trans-hydroxy proline with L-phenylalanine ethyl ester, deprotection of the amino group followed by an deacetimisation and finally desilylation. This final product has spectral data that agree with the already reported data in literature.

Keywords: diketopiperazine, hydroxyproline, phenylalanine