Evaluation of analgesic effect of a Ammania baccifera Linn. in mice

  • R Dhanapal Department of Pharmaceutics, Rural College of Pharmacy, Devanahalli, Bangalore-562110, Karnataka, India
  • BM Vrushabendraswamy Department of Pharmacology, Rural College of Pharmacy, Devanahalli, Bangalore-562110, Karnataka, India
  • T Murugesan Duke Center for Nicotine and Smoking Cessation Research, Department of Psychiatry, Duke University Medical Center, Durham, NC 27705, USA
  • K Chandramohan Department of Pharmaceutics, Rover College of Pharmacy, Perambalur, Tamilnadu, India
  • K Sridharchandanam Department of Pharmaceutical Chemistry, Rural College of Pharmacy, Devanahalli, Bangalore - 562110, Karnataka, India
  • S Kavimani Mother Theresa Research Institute of Health Sciences, Pondicherry-1, India
Keywords: <i>Ammania baccifera</i>, chemical models, nociception, analgesic activity

Abstract

The analgesic activity of the ethanol extract of Ammania baccifera Linn whole plant (EEAB) was investigated in chemical models of nociception in mice. EEAB at doses of 200, 400 and 600mg/kg i.p produced an inhibition of 20.7%, 43.4% and 72.9%, respectively, of the abdominal writhes induced by acetic acid in mice. In the formalin test, the administration of 200,400 and 600mg/kg i.p had no effects in the first phase (05 min) but produced a dosedependent analgesic effect on the second phase (1540 min) with inhibitions of the licking time of 27.3%, 47.7% and 57.4%, respectively. These observations suggest that Ammania baccifera possesses some analgesic activity.

Keywords: Ammania baccifera, chemical models, nociception, analgesic activity

West African Journal of Pharmacology and Drug Research Vol. 20(1&2) 2005: 31-34

Published
2005-12-05
Section
Articles

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eISSN: 0303-691X