Clionasterol, a Triterpenoid from the Kenyan Marine Green Macroalga Halimeda macroloba

  • Thomas Dzeha Kenya Marine Fisheries Research Institute, P.O. Box 81651 Mombasa, Kenya
  • Marcel Jaspars Department of Chemistry, University of Aberdeen, AB24 3UE Scotland, UK
  • Jioji Tabudravu Department of Chemistry, University of Aberdeen, AB24 3UE Scotland, UK
Keywords: clionasterol, macroalga, Halimeda macroloba, spectroscopy, bioprospecting, Kenya

Abstract

Keywords: clionasterol, macroalga, Halimeda macroloba, spectroscopy, bioprospecting, Kenya

The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.

Western Indian Ocean Journal of Marine Sciences Vol.2(2) 2003: 157-161
Published
2004-05-11
Section
Articles

Journal Identifiers


eISSN: 0856-860X
print ISSN: 0856-860X