Renal gross morphological restorative effects of <i>Curcuma longa</i> on sildenafil induced nephrotoxicity among male albino rats.

Abstract

Background: Sildenafil is a phosphodiesterase inhibitor used in the management of erectile dysfunction and management of pulmonary hypertension. Curcuma longa is a traditional herbal plant that is commonly used as a diet in Africa and Asian countries. It has a variety of benefits including; antioxidant, anti-cancerous, management of diabetes and respiratory diseases. The objective of this study was to evaluate the renal gross morphological changes in restorative effects of Curcuma longa on sildenafil induced nephrotoxicity among male albino rats. Methodology: A total of 25 male albino rats were used and classified control or experimental group. Simple random sampling method was used to allocate them into each group. Animals in group1 were only fed on feeds and water ad libitum, group 2 to 5 received Sildenafil 1mg/gm bwt for 15 days. Animals in group 3,4 and 5 were further subjected to Curcuma longa at calculated dose of low, medium and high respectively. Animals in group 2 were sacrificed 4 hours post last dose and the remaining animals were sacrificed 7 days later. On sacrificing gross morphometrics were done. Results: It was observed that mean weight of rat, weight and volume of kidney increased significantly (p=0.0001) in medium and high dose Curcuma longa as compared to Sildenafil induced nephrotoxicity group. The mean length and thickness in medium and high dose Curcuma longa increased significantly (p=0.0001) as compared to Sildenafil induced nephrotoxicity group. Conclusion: Medium and high dose Curcuma longa have renal gross morphological effects on sildenafil induced nephrotoxicity among male albino rats.