Utilization of carbon and nitrogen sources by <i>Streptomyces kanamyceticus</i> M 27 for the production of an Anti bacterial antibiotic

Abstract

We tested a number of carbon and nitrogen compounds for their effect on the production of an antibacterial antibiotic by Streptomyces kananmyceticus M27. Dextrose was found to be the most suitable carbon source, though maltose, sucrose, and soluble starch gave moderate yields. (NH4)H2PO4 and yeast extract were adequate nitrogen sources for antibiotic production. There was, however, no direct relation between the growth of the organism and antibiotic formation. The pH of the medium might be an important factor for antibiotic formation, as media giving high antibiotic yields showed an alkaline pH.