Evaluation of the wound healing activity of <i>Cinnamomum zeylanicum</i> extract on experimentally induced wounds in rats

Abstract

The present study was undertaken to determine the effect of Cinnamomum zeylanicum on experimentally induced excision wounds in rats. Thirty-two rats were divided into four groups of eight rats each. Group A received a placebo containing 0.75% cinnamon, Group B received a placebo containing 1.5% cinnamon, Group C as a control group did not receive any treatment, and finally, Group D received blank placebo; Groups C and D were considered as one group (standard). The results were taken on days 3, 7, 14 and 21 and a histological evaluation was carried out on the samples. The result shows that cinnamon extract had a significant (p<0.05, **p<0.01) effect on wound healing; it accelerated the healing process of the wounds. Significant enclosure rates were seen after 7 days of study. The present study proved that C. zeylanicum was effective in treating experimentally induced wounds and hasten healing, showing a dose-dependent treatment trend. It especially increased epithelialization in treatment groups compared to other groups.

Key words: Cinnamomum zeylanicum, induced excision, epithelialization, wound healing.