Successful treatment of benign lesions by bis 3- azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II) in albino rats

Abstract

The study of the effect of bis 3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II) as chemotherapeutic agent was undertaken with the intention of studying the effects in 7,12-dimethylbenz[a] anthracene (DMBA) and tetradecanoyl phorbol-13-acetate (TPA) induced chemical carcinogenesis on skin of 5 - 7 weeks old healthy albino rats. The animals were divided into 5 groups (A, B, C, D and E) of twenty each. The rats were treated with carcinogens for 15 weeks and then the curative effect of bis 3-azophenyl-4-hydroxy- 6-methyl-pyran-2-one cobalt (II) was observe. The bis 3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II) prevents malignant conversion of  chemically induced benign tumors and did not kill cancer cells but change them to normal cells. It was concluded that if the complex is given in the pre-malignant phase of tumor development, it decreases the risk of malignant transformation.

Key words: 7,12-Dimethylbenz[a] anthracene (DMBA), tetradecanoyl phorbol-13-acetate (TPA), complex {bis- 3-azophenyl-4-hydroxy-6-methyl-pyran-2-one cobalt (II)}, skin cancer.