Preliminary studies on cytotoxic effect of fungal taxol on cancer cell lines

  • V Gangadevi
  • J Muthumary
Keywords: Endophytic fungi, medicinal plants, taxol, cytotoxic activity, apoptosis.

Abstract

Taxol is an important anticancer drug used widely in the clinical field. Some endophytic fungi were isolated from selected medicinal plants and screened for the production of taxol. The effect of cytotoxicity of fungal taxol isolated from fungal endophytes was investigated by apoptosis method. The
presence of taxol in the culture filtrate of endophytic fungi was determined by thin layer chromatography. The fungal taxol isolated from the organic extract of six fungal cultures, had strong cytotoxic activity towards BT 220, H116, Int 407, HL 251 and HLK 210 human cancer cells in vitro.
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eISSN: 1684-5315