African Journal of Biotechnology

The AJOL site is currently undergoing a major upgrade, and there will temporarily be some restrictions to the available functionality.
-- Users will not be able to register or log in during this period.
-- Full text (PDF) downloads of Open Access journal articles will be available as always.
-- Full text (PDF) downloads of subscription based journal articles will NOT be available
We apologise for any inconvenience caused. Please check back soon, as we will revert to usual policy as soon as possible.

Anti-pyretic, anti-inflammatory and anti-diarrhoeal properties of Faidherbia albida in rats

AY Tijani, MO Uguru, OA Salawu


Faidherbia albida Del. (local name: Gawo) is employed traditionally to treat disorders such as fever, diarrhoea, urticaria, vomiting, cough, rheumatism and heamorrhage. The present study was carried out
to scientifically appraise some of the folkloric uses of the plant. The crude aqueous extract was studied for acute toxicity, its anti-pyretic, anti-inflammatory and anti-diarrhoeal effects using yeast-induced
pyrexia, kaolin-induced oedema and castor oil-induced diarrhoeal models in rats. The extract was not lethal to the rats dosed at 5000 mg/kg body weight. At a dose of 500 mg/kg body weight, it significantly
(P < 0.05) decreased yeast-induced pyrexia in rats. At doses of 250 and 500 mg extract/kg body weight, the extract significantly (P < 0.05) inhibited kaolin-induced acute inflammation and reduced frequency of
diarrhea in the rats. These results indicate that aqueous extract of F. albida possesses potent antipyretic, anti-inflammatory and anti-diarrhoeal effects and thus pharmacologically justifies its folkloric
use in the management of fever, rheumatic inflammatory conditions and diarrhoea.

AJOL African Journals Online