Thyroidal angiogenesis in zebrafish (Danio rerio) exposed to high perchlorate concentration

  • IÜ Sema
  • Ö Karayazi
  • A Isisag
Keywords: Perchlorate, zebrafish, thyroid, angiogenesis


As a well known environmental contaminant, perchlorate inhibits thyroidal iodide uptake and reduces thyroid hormone levels. In zebrafish (Danio rerio) exposed to high concentrations of sodium perchlorate (200, 350 and 500 mg/L) for 10 days, remarkable angiogenesis was identified, not only
histopathologically but also statistically by counting of the small, medium and large sized (grades 1 to 3) vessels per unit area. Angiogenic response is concluded as the most sensitive parameter for rating of high concentrations of perchlorate exposure.

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eISSN: 1684-5315