Anti-inflammatory activity of <i.Wigandia urens</i> and <i>Acalypha alopecuroides</i>

Abstract

The anti-inflammatory activity of the chloroform, methanol and aqueous extracts of Wigandia urens and Acalypha alopecuroides were investigated on carrageenan-induced paw edema at doses of 400 mg/kg. The three extracts of W. urens, and the aqueous extract of A. alopecuroides caused significant
inhibition of the edema (58.1±6.5% and 63.5±5.4%, respectively). Indomethacin was used as positive control (8 mg/kg), and inhibited edema by 66.3±5.2%. The methanol extract of W. urens and the aqueous extract of A. alopecuroides, at doses of 200 mg/kg, inhibited pellet implantation-induced granuloma formation by 69.4±6.5 and 70.6±6.6%, respectively. These levels of inhibition are higher than those exhibited by naproxen at doses of 50 mg/kg (46.1±7.1%). Both extracts showed activity on adjuvantinduced arthritis in rats, with the best effect being observed after 96 h (82.2±4.6 and 80.6±7.3%, respectively).