Effect of propionate on the production of natamycin with <i>Streptomyces gilvosporeus</i> XM-172

Abstract

This study described the influence of feeding short-chain fatty acids and alcohols on natamycin production in the glucose basal medium, produced by Streptomyces gilvosporeus XM-172. The highest natamycin production was obtained with feeding propionate as compared to other precursors. The optimal propionate concentration and feeding time were 6 g L^-1 and early log phase, respectively. This optimal propionate feeding strategy led to a natamycin production of 6.72 g L^-1, which was nearly 85% higher than that of the control. It was firstly revealed that propionate could greatly promote natamycin biosynthesis by S. gilvosporeus.

Key words: Precursor, propionate, natamycin production, Streptomyces gilvosporeus XM-172.