T lymphocyte subsets in prostate cancer subjects in south eastern Nigeria
Humoral and cellular mechanisms play roles in immune response to foreign antigens. The present study was designed to determine the T lymphocyte subsets (CD4 + T cells, CD8 + T cells and CD4/CD8 ratio) in the prostate cancer subjects and control subjects. CD4 + T cells (`l/count) and CD8 + T cells (`l/count) were estimated using flow cytometric method by Partec while CD4/CD8 ratio was calculated from the results obtained from the CD4 + T cells and CD8 + T cells. CD4 + T cells and CD8 + T cells decreased significantly while the CD4/CD8 ratio increased significantly in the prostate cancer subjects compared to the
control subjects. The suppressed CD4 + and CD8 + T cell counts in prostate cancer subjects may indicate immune instability in the prostate cancer subjects.
Key words: T lymphocyte subsets, prostate cancer, tumour