Balanites aegyptiaca protection against proliferation of different cancer cell line
Background: The aim of the present study was to evaluate in vivo anti-tumor activity of Balanites aegyptiaca fruits extracts in addition to its role in cell cycle and apoptosis.
Materials and Methods: Antitumor activities of ethylacetae extract (EAE), ethanol extract (EE) and chloroform extract (CE) were tested against different cell line Hep-2, MCF-7, HL-60 and HCV29T. Calculation of the IC50 values for these extracts confirmed that the most potent plant extract was EAE (40 ug/ml) followed by EE (55ug/ml), CE (61ug/ml).
Results: The ethanolic and chloroform extracts showed lower difference in their potency, while the EAE was found to be more active indicating for nonpolar active principles responsible for the anti-proliferative activity. The ethanolic extract was three times higher active than the chloroform extract. The results obtained showed that EAE exert a significant anti-proliferative, enhancement of apoptosis and modulation of cell cycle phases compared with vincristine.
Conclusion: The presence of alkaloids, flavonoids and Phenolics increase its efficiency as anti-proliferative action. EAE has promising anti-cancer activity with higher activity than EE or CE extracts
Key words: antiproliferative, apoptosis, Balanites aegyptiaca
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.