Cardioprotective roles of the Chinese medicinal formula Bao-Xin-Tang on acute myocardial infarction in rats

  • Yang Wang
  • Weihao Wang
  • Weijun Peng
  • Weiping Liu
  • Weijun Cai
  • Zian Xia
  • Honggeng Zhang
  • Zhihua Xing
Keywords: Bao-Xin-Tang, cardioprotective, infarction size, anti-inflammatory, anti-oxidative

Abstract

Background: Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored.

Materials and Methods: The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities.

Results: The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size.

Conclusion: The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties.

Keywords: Bao-Xin-Tang, cardioprotective, infarction size, anti-inflammatory, anti-oxidative

Published
2017-02-21
Section
Articles

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eISSN: 0189-6016