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African Journal of Traditional, Complementary and Alternative Medicines

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Flavonoids, anti-inflammatory activity and cytotoxicity of Macfadyena unguis-cati l.

EA Aboutabl, FA Hashem, AA Sleem, AA Maamoon

Abstract




Ethyl acetate and ethanol extracts of unflowering aerial part of Macfadyena unguis-cati L.(Fam. Bignoniaceae) were found to be rich in phenolic compounds. From ethyl acetate extract,six flavonoids were identified, 8, methoxy, acacetin, 7-O glucoside; 6, methoxy apigenin 7-O glucoside; 4`-O methyl scutellarin, 6- O apiosyl galactoside; acacetin, 7-O glucosyl, 8-C rhamnosyl, 3-O-α arabinofuranoside; 4`-methyl, 6- methoxy
kaempferol, 7-O, 8-C diglucoside and vicenin II were isolated, while 6, methoxy, acacetin 7-O glucoside; and quercitrin were isolated from ethanol extract. These compounds were characterized and identified by their physicochemical and spectral data. The crude ethanol extract exhibited significant anti-inflammatory activity (80.47%) and moderate cytotoxic activity against lung cell line.

Keywords: Macfadyena unguis-cati L., Bignoniaceae, flavonoids, anti-inflammatory, cytotoxicity.

African Journal of Traditional and Complementary Medicine Vol. 5 (1) 2008: pp. 18-26



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