Anti-Nociceptive And Anti-Inflammatory Activities Of Aqueous Leaves Extract Of Ocimum gratissimum ( Labiate ) In Rodents
The aqueous leaves extract of Ocimum gratissimum was investigated for anti-nociceptive and antiinflammatory effects in mice and rats. The models used to study the effect on nociception are the acetic acidinduced abdominal constriction test, hot- plate method in mice. The anti-inflammatory effect was investigated employing the formalin-induced hind–paw oedema in rats. The extract caused a significant (p<0.05), dosedependent inhibition of acetic acid-induced writhing and hot-plate method .The extract also exhibited antiinflammatory effect which was significant (P<0.001) at all the three doses. .The intraperitoneal LD50 value of the extract was 1264.9mg/kg body weight in mice. Preliminary phytochemical screening revealed the presence of alkaloids, saponins, tannins and flavonoids. The results suggest the extract contained pharmacologically active principles, and supports the local application of the plant in painful and inflammatory conditions.
Keywords: Ocimum gratissimum, anti-nociceptive, anti-inflammatory.
Afr. Jnl of Trad Comp Alt medicine Vol. 5 (2) 2008: pp. 141-146
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