A study on the inhibitory effect of Solanum lyratum thumb extract on lewis lung carcinoma lines

  • Z Xiao
  • A Wang
  • X Wang
  • S Shen
Keywords: Solanum lyratum Thunb, tumour-bearing mice, anti-tumour effect

Abstract

The objective of this paper was to observe the effects of Solanum lyratum Thunb extract on tumour inhibition, immune function and survival time of tumour-bearing mice. Lung carcinoma-bearing mouse model was  established, the tumour-bearing mice were divided into model group, CTX group, Solanum lyratum Thunb extract high-dose group and low-dose group. By the examination of tumour inhibition rate of Solanum lyratum Thunb extract in Lewis lung carcinoma-bearing mice and determination of the number of NK cells and T cell subsets, the survival rate of tumour-bearing mice was observed. Solanum lyratum Thunb extract had some anti-tumour effect in Lewis tumour-bearing mice. The tumour inhibition rate of high-dose group reached 46.28%, and the tumour inhibition rate of low-dose group was 31.42%. Solanum lyratum Thunb extract can improve the NK cell activity of Lewis tumour-bearing mice, increase the number of CD4 cells in the tumour-bearing mice, and significantly increase the  survival rate of tumour-bearing mice. The study concluded that Solanum lyratum Thunb extract has some anti-tumour effect and can improve  immune function and survival rate of tumour-bearing mice.

Keywords: Solanum lyratum Thunb; tumour-bearing mice; anti-tumour effect

Published
2013-10-14
Section
Articles

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eISSN: 0189-6016