Glucose tolerance in <i>Bufo gutturalis</i> (Power) after destruction of the islets of Langerhans

Abstract

An investigation was undertaken to determine the glucose tolerance response in Bufo gutturalis after alloxan induced diabetes. The pancreatic β-cells were completely destroyed 24 h after the administration of 240 mg alloxan/kg body mass. However, animals treated In this manner showed a normal response curve. When the alloxan dosage and treatment period were Increased, typically diabetic tolerance was apparent.