Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives

  • K. K. Valluri
  • I. V. K. Viswanath
  • P. V. V. S. Naga Raju
  • B. Rajasekher
  • B. R. Dasu
Keywords: Synthesis, Quinoline, 1, 3, 4-thiadiazolo pyrimidin, Spectral data, Potential activity


A series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives (5a-h) have been developed using 4-amino-8-fluoro-quinoline-3-carboxylic acid ethyl ester (1) as raw material and by involving 8-fluoro-4-methylsulfanylthiocarbonylamino-quinoline-3-carboxylic acid ethyl ester (2), 8-fluoro-4-hydrazine thiocarbonylamino-quinoline-3-carboxylic acid ethyl ester (3) and 3-amino-7-fluoro-2-mercapto-3H-pyrimido-[5,4-c]quinolin-4-one (4) as intermediates. The title compounds after structure elucidation were used in vitro to find their antibacterial ability towards different micro-organisms.


KEY WORDS: Synthesis, Quinoline, 1,3,4-thiadiazolo pyrimidin, Spectral data, Potential activity


Bull. Chem. Soc. Ethiop. 2017, 31(2), 337-344.   



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eISSN: 1726-801X
print ISSN: 1011-3924