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Bulletin of the Chemical Society of Ethiopia

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A 3D polyhedral metal–organic framework as drug carrier for controllable release

E. H. Zhou, R. Wang, J. Wu, S. W. Qiu, J. Q. Liu, H. R. Zhong, H. D. Zeng, J. W. Xu, J. C. Jin

Abstract


A new fabrication of {[H3O][Cu6(tpta)3(DMA)4(COO)]∙12H2O∙7DMA} (1) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1. Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.

               

KEY WORDS: Drug delivery, Release, Porous MOF

 

Bull. Chem. Soc. Ethiop. 2017, 31(3), 457-463. 

DOI: http://dx.doi.org/10.4314/bcse.v31i3.9




http://dx.doi.org/10.4314/bcse.v31i3.9
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