Bulletin of the Chemical Society of Ethiopia

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Synthesis, characterization and crystal structures of hydrazone compounds derived from isonicotinohydrazide

M. T. Zhu, X. Y. Qiu, S. J. Liu, L. Y. He, D. Z. Xu, Z. You


New isonicotinohydrazone compounds, N’-(3-bromobenzylidene)isonicotinohydrazide (1) and N’-(2,3-difluorobenzylidene)isonicotinohydrazide (2), were prepared and structurally characterized by elemental analysis, IR, UV and 1H NMR spectra, and single crystal X-ray determination. Compound 1 crystallizes in the monoclinic space group P21/n with unit cell dimensions a = 7.600(2) Å, b = 11.365(2) Å, c = 14.412(2) Å, β = 101.748(2)º, V = 1218.7(4) Å3, Z = 4, R1 = 0.0335, and wR2 = 0.0745. Compound 2 crystallizes in the triclinic space group P-1 with unit cell dimensions a = 7.6241(6) Å, b = 11.3937(9) Å, c = 14.335(1) Å, α = 79.664(1)º, β = 75.990(1)º, γ = 71.159(1)º, V = 1136.5(2) Å3, Z = 4, R1 = 0.0345, and wR2 = 0.0940. Structures of both compounds are stabilized by hydrogen bonds and π···π interactions.


KEY WORDS: Isonicotinohydrazone, Crystal structure, Hydrogen bonds, X-ray diffraction


Bull. Chem. Soc. Ethiop. 2018, 32(1), 125-132

AJOL African Journals Online