PROMOTING ACCESS TO AFRICAN RESEARCH

Bulletin of the Chemical Society of Ethiopia

Log in or Register to get access to full text downloads.

Remember me or Register



Utility of amino acid coupled 1,2,4-triazoles in organic synthesis: synthesis of some new antileishmainal agents

A. M. M. El-Saghier, M. A. A. Mohamed, O. A. Abdalla, A. M. Kadry

Abstract


Starting from 3-amino-5-(2-hydroxyphenyl) amino acid coupled triazoles 1a-e, new 3-(2-hydroxyphenyl)-3H-imidazo[2,1-c][1,2,4]triazol-6(5H)-one 2a,b, 3b,d, 6a and 3-N-arly(alkyl) amino acid coupled triazoles 4b,d, 7a,c,d,e have been synthesized as potential antileishmanial agents. The structures of the newly synthesized compounds were confirmed using elemental and spectral analyses (FT-IR, 1H-NMR, 13C-NMR and MS). The in vitro antileishmanial potency of the synthesized compounds was evaluated compared to Amphotericin B deoxycholate and miltefosine as lead references. Compounds 2b, 7d and 7e showed perfect IC50 values corresponding to amphotericin B and more patent than miltefosine against L. aethiopica promastigotes.

               

KEY WORDS: Amino acids, Coupled, Imidazo-1,2,4-Triazole, Promatigote, Antileishmanial

 

Bull. Chem. Soc. Ethiop. 2018, 32(3), 559-570.

DOI: https://dx.doi.org/10.4314/bcse.v32i3.14




AJOL African Journals Online