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Bulletin of the Chemical Society of Ethiopia

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EFFICIENT SODIUM SELENATE-CATALYZED SYNTHESIS OF 3,4-DIHYDRO-2(1H)-PYRIMIDINONES AND –THIONES UNDER SOLVENT-FREE CONDITIONS

Rahim Hekmatshoar, Maryam Heidari, Majid M. Heravi, Bita Baghernejad

Abstract


Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or –thiones in excellent yields.
KEY WORDS: Dihydropyrimidinones, Sodium selenate, Biginelli reaction, Three component reaction


Bull. Chem. Soc. Ethiop. 2009, 23(1), 141-144.



http://dx.doi.org/10.4314/bcse.v23i1.21312
AJOL African Journals Online