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Bulletin of the Chemical Society of Ethiopia

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Syntheses and spectral studies of novel ciprofloxacin derivatives

Pradeep Yadav, Y.C. Joshi

Abstract


Reaction of 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (ciprofloxacin) with thiazole/benzothiazole diazonium chloride afforded piperazine substituted ciprofloxacin derivative. The acid part of these derivatives was further condensed with various β-diketones to get 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(thiazol-2-yldiazenyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid derivatives (5a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivatives (5f-j). Structures of these compounds were established on the basis of spectral studies.

 

KEY WORDS: Ciprofloxacin, Thiazole, Benzothiazole, β-Diketone

 

 

Bull. Chem. Soc. Ethiop. 2008, 22(3), 459-464.  




http://dx.doi.org/10.4314/bcse.v22i3.61246
AJOL African Journals Online