Efficient and convenient synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by phase transfer catalysis

  • Yu Lin Hu Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China
  • Xing E Zhao Nanjing Simcere Pharmaceutical Co., Ltd, Nanjing 210042, PR China
  • Ming Lu Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China
Keywords: Carboxylic anhydrides, Carboxylic acids, SO<sub>4</sub><sup>2−</sup>/ZrO<sub>2</sub>, Phase transfer catalysis

Abstract

An efficient and convenient procedure for the synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by PEG-1000 phase transfer catalysis has been developed. The reactions proceeded under mild and solvent-free conditions to provide the carboxylic anhydrides in good to excellent yields. The product can be isolated by a simple extraction with organic solvent, and the catalyst system can be recycled or reused without any significant loss of catalytic activity.

KEY WORDS: Carboxylic anhydrides, Carboxylic acids, SO42-/ZrO2, Phase transfer catalysis

 

Bull. Chem. Soc. Ethiop. 2011, 25(2), 255-262.
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Articles

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eISSN: 1726-801X
print ISSN: 1011-3924