Synthesis and antitubercular activity of 4-oxo-thiazolidine derivatives of 2-amino-5-nitrothiazole

  • P. Samadhiya
  • R. Sharma
  • S.K. Srivastava
Keywords: Synthesis, 2-Amino-5-nitrothiazole, Thiazolidinone, Antimicrobial, Antitubercular

Abstract

New series of N-[3-(2-amino-5-nitrothiazolyl)-propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(a-j) have been synthesized from 2-amino-5-nitrothiazole as a starting material. The structure of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the final synthesized compounds 5(a-j) were screened for their antibacterial and antifungal activities against some selected bacteria and fungi with their MIC values and antitubercular activity screened against M. tuberculosis.

 


KEY WORDS: Synthesis, 2-Amino-5-nitrothiazole, Thiazolidinone, Antimicrobial, Antitubercular

 

Bull. Chem. Soc. Ethiop. 2013, 27(2), 249-263.

DOI: http://dx.doi.org/10.4314/bcse.v27i2.10

Published
2013-05-17
Section
Articles

Journal Identifiers


eISSN: 1726-801X
print ISSN: 1011-3924