Current Microbial Pattern of Patients Presenting with Pre-Labour Rupture of Membranes (PROM) at Kenyatta National Hospital, Nairobi, Kenya

Abstract

Objective: To determine the microbial pattern of patients presenting with PROM.

Design: Case Control Study.

Setting: Kenyatta National Hospital, labour ward, Nairobi Kenya.

Subject: Fifty antenatal patients with premature Rapture of Membranes and 50 controls.

Results: A total of 100 questionnaires and laboratory liquor microscopic culture and sensitivity results  were analysed, 50 from the PROM group and 50 in the control group. There was no statistically significant difference in baseline social demographic and obstetric characteristics between the two groups. As for the mode of delivery 70% in PROM had SVD compared to 48% of the controls with 30% undergoing  Caesarean section in PROM group and 52% of the controls. There were no complications recorded in the mothers both at and after delivery. Escherichia coli was the most common bacterial isolated accounting for 66.7% of bacterial isolate in the PROM group. Other isolates were staphylococcus species,  staphylococcus and streptococcus viridans.With regard to anti-biotic sensitivity, 83.3% sensitivity to both cefuroxime and gentamicin while co-amoxiclav had 67.7% sensitivity. Among the newborns, in the PROM group 10% had Apgar score <7 with NBU admission rates of 20% and 6% respectively between the PROM and control groups respectively.

Conclusion: Escherichia coli was the most common bacterial isolate in PROM and cefuroxime is the  anti-biotic of choice where it’s not possible to perform endocervical swab, cultures and sensitivity.